20. NWO Crossover Grant INTENSE -- Innovative NeuroTEchNology for SociEty (2020 --), main applicant: prof. dr. P R. (Pieter) Roelfsema (The Netherlands Institute for Neuroscience, KNAW). The project INTENSE will develop brain implants to improve the lives of people who are blind, deaf or paralysed or who suffer from epilepsy. The research will combine the strongly increased knowledge about our brain with new possibilities within neurotechnology with the aim of realising new solutions and commercial opportunities.
19. Tinnitus House (2018 -- ). Founders: prof.dr. D. de Ridder (U. Gent), prof.dr.ir. W.A. Serdijn (TU Delft), E.M. van der Velden (independent translational researcher), J. van Gent (Irion Technologies), P. Storey (PSF Medical) and R. Woering (Epona Consultancy). Tinnitus House is established as part of the Braininnovations Foundation and has set itself the goal of collecting data from as many patients as possible in order to gain insight into the factors that cause tinnitus to occur and the factors that can cause tinnitus to decrease or disappear completely. The idea behind Tinnitus House is cooperation between everyone who tries to help to solve the problem of tinnitus: researchers (TU Delft, Braininnovations Foundation), care providers, fundraisers (Tinnitusfree, Gaby Olthuis foundation), people who inform (Hoormij, NVVS) and patients.
18. Medical Delta 2.0 programme "Cardiac Arrhythmia Lab" (2019 --), programme leaders: prof.dr. N.S.M. de Groot (ErasmusMC), prof.dr. B. Brundel (ErasmusMC), prof.dr.ir. A.-J. van der Veen (TU Delft) and prof.dr.ir. W.A. Serdijn (TU Delft). Cardiac arrhythmias are the cardiovascular epidemic of the 21th century. Unfortunately, effectiveness of arrhythmia therapy is low due to insufficient knowledge of underlying electropathology, which is defined as electrical conduction disorders caused by damage of cardiac tissue. Also, there are currently no tools to identify and target electropathology. The mission of the medical delta team is to decrease the cardiac arrhythmia burden by providing patient-tailored therapy. Hereto, we aim to design and test novel bio-electrical diagnostic tools, unravel arrhythmia-related electropathology and develop innovative therapies targeting electropathology. This goal requires construction of bio-electrical recording and processing techniques to be utilized to unravel and target electropathology. Therefore, we propose to 1) design (multi-modal) devices for identifying arrhythmia-related electropathology, in both in-vitro cell- and tissue cultures and in-vivo animal or human hearts. This includes a first-of-a-kind arrhythmia-on-a-chip model to study arrhythmia mechanisms, identify novel therapeutic targets and test innovative therapies, 2) generation of high-resolution electrical signal fingerprints of patients using advanced signal-processing techniques and 3) unravelling electropathology in humans by integrating high-resolution signal fingerprints with blood- and tissue-based biomarkers and cardiac images. In this way, we provide a worldwide unique individualized, multi-disciplinary management strategy of patients with cardiac arrhythmias.
17. Medical Delta 2.0 programma "NeuroDelta" (2019 --), programme leaders: prof.dr. A. van den Maagdenberg (LUMC), prof.dr. C. de Zeeuw (Erasmus MC) and prof.dr.ir. W.A. Serdijn (TU Delft). Brain disorders that involve multiple brain regions are notoriously difficult to treat and impose a huge burden on society at large. One of the main problems is that many patients suffering from such brain disorders are diagnosed relatively late; to improve prevention and treatment we should detect them as early as possible. Our NeuroDelta Consortium ultimately aims to develop reliable, easy-to-use, systems for long-term neuromonitoring and neuromodulation of patients with widespread abnormalities of brain activity that lead to dysfunctions in both individual and social settings. For the current project we will develop and evaluate such a system for mouse models suffering from these types of disorders, paving the way for clinical applications. More specifically, we will develop Neuro-E-Mit (Neuro E-mediated Mouse InTerface), which will allow us to monitor and modulate activity simultaneously in multiple brain regions of multiple animals, and we will test this system in mouse models for two disorders with widespread brain dysfunction that lead to deficits in individual and social behavior: migraine and autism. Applying bio-electronics, acoustrodes and optrodes in combination with cutting-edge artificial intelligence and machine-learning algorithms for analyses this approach will yield insight in brain dysfunction allowing fast assessment of disease diagnosis, progression and treatment.
16. NWO Applied and Engineering Sciences (NWO-TTW) project (16105) "ReaSONS 2 Demo: Realtime Sensing of Neural Signals to Demonstrator" (2017 - 2019), project leader: prof.dr.ir. W.A. Serdijn. We recently developed a radically new technique, coined "additive companding", which solves important technological limitations of current neural recording systems. The technology has been patented, tested in the lab as proof of concept and is now ready to be developed further into a prototype. The foreseen prototype will allow for continuous and complete monitoring of neural activity, offers better performance and consumes drastically less volume (<400 µm x 400 µm x 400 µm) and energy (<<1 mW) than neural monitoring systems that currently exist or are under development. Clinically, the continuous and complete neural monitoring will offer new insights into the exact workings of nerve and brain tissue and it becomes possible to take the first step into the development of active medical implants that adjust themselves to the therapeutical needs of the patient without subjective measures. This, ultimately, enhances the health-related quality of life of patients with nerve and/or brain disorders and allows for a better treatment of a larger variety of nerve and brain disorders.
15. NWO Take-Off Grant project (16026) "Improving pressure ulcer prevention with smart mobility monitoring in healthcare institutions" (2017 --), project leader: prof.dr.ir. W.A. Serdijn. Pressure ulcer wounds are a global problem in healthcare institutions, still. These wounds cause a lot of pain and discomfort for the patient, a high workload for the caregivers and cost a lot of money, in the EU alone already more than 15 billion Euros each year. TU Delft spin-off Momo Medical has developed a smart sensor bed sensor that solves this problem. In this project, the following steps are taken to test the smart bed sensor in practice, in the Living Lab of the Reinier de Graaf Hospital. In addition, further commercial development is done by approaching more potential customers and understanding the cost structure of the product better when scaling up.
14. Dutch Technology Foundation (STW) and (Hartstichting) project (14728) "AFFIP -- Atrial Fibrillation FIngerPrinting: Spotting Bio-Electrical Markers to Early Recognize Atrial Fibrillation by the Use of a Bottom-Up Approach" (2016 --), project leader: dr. N.M.S. de Groot (ErasmusMC), workpackage leader WP4, High Density Mapping Array: prof.dr.ir. W.A. Serdijn. Atrial fibrillation (AF) is a progressive disease and associated with severe complications such as stroke. The goal of this project is to develop age and gender based, bio-electrical diagnostic tests, the invasive and non-invasive AF Fingerprint, which consists of electrical atrial signal profiles and levels of atrial specific tissue/blood biomarkers. In daily clinical practice, this novel diagnostic instrument can be used for early recognition or progression of AF by determination of stage of the electropathology. As such, AF Fingerprinting enables optimal AF treatment, thereby improving patient’s outcome.
13. Dutch Technology Foundation (STW) project (13598) "Digitally Dominant Analog Blocks for Ultra-Low-Power Wireless Sensor Network" (2016 --), project leader: prof.dr.ing. L.C.N. de Vreede (TU Delft), workpackage leader WP2 and WP4: prof.dr.ir. W.A. Serdijn. The progress of ultra-low-cost, ultra-low-power (ULP) wireless sensor network (WSN) nodes with advanced bi-directional communication, sophisticated sensors and powerful digital processing is hindered by the continued lack of digitization of its two major subsystems: frequency synthesizers (both providing radio-frequency carrier and clock to the digital processor) and power management converters. This work aims to address these concerns by investigating and demonstrating digitally intensive ULP solutions of all-digital phase-locked loops (ADPLL) and inductor/capacitor-based DC-DC switching converters.
12. EU ECSEL JU project "InForMed -- An Integrated Pilot Line for Medical Devices" (2015 --), project leader: dr. S. Swaving. Wouter Serdijn is involved in WP4, Demonstrator 2: Advanced devices for electrophysiology. In the InForMed project an integrated pilot line for medical devices will be established, covering the complete innovation chain from technology concept to system qualification. It will include micro-fabrication, assembly and even the fabrication of smart catheters. Uniquely, the integrated pilot line is hosted by a large industrial end-user, and is specifically targeted and equipped to bridge the gap in the landscape of micro-fabrication of medical devices between concept creation and full-scale production.
11. Research Program "MASSIVE -- Autonomous Vital Signs Monitoring" (2013 - 2019 ), program leader: prof.dr.ir. W.A. Serdijn. In this research program, supported by CNPq, CAPES, CSC and Delft University of Technology, we work on electroceuticals that wirelessly receive power and wirelessly transmit vital signs like body temperature, ECG, EMG, EEG and ECoG.
10. Research Program "SINs -- Smart Implantable Neurostimulators" (2009 -- ), TUD program leader: prof.dr.ir. W.A. Serdijn. In this research program that is a collaboration of Delft University of Technology (4 sections, 3 departments), Erasmus University Rotterdam, Dunedin School of Medicine, Otago University, University of Texas at Dallas, the Brain Research center for Advanced, Innovative and Interdisciplinary Neuromodulation and Irion Technologies, we push the research and development of technology for research on and treatment of a multitude of brain disorders, a.o., tinnitus and addiction.
9. Dutch Technology Foundation (STW) project (11693) "REASONS – Realtime Sensing of Neural Signals" (2011 – 2016), project leader: prof.dr.ir. W.A. Serdijn. This project targets the development of a completely new readout system for measuring the so called electrically evoked compound action potential (eCAP) coming from the auditory nerve. To develop this readout system, new electronic circuitry will be designed based on state of the art technologies integrated with the electrode itself. Existing systems will be tested extensively to develop novel measurement algorithms for the new readout system. Animal experiments will be performed on existing and new readout systems. We expect to come up with circuits and systems for reading out neural responses that offer more functionality, better performance and enjoy a drastically reduced form factor and power consumption. Clinically, the neural response will give new insight in the potential of eCAP recordings and take the first step in moving toward fitting to the patient without subjective data. Future patients will be rehabilitated better and faster with the newly developed methods.
8. STW project (10056) "SMAC-IT – Smart Implantable Cochlear Implants" (2008 – 2013). Dr. Serdijn has been workpackage leader in the STW project SMAC-IT, funded as part of the SMART-SIP program. In this project, research has been conducted and technologies developed to address the drawbacks of current cochlear implants by: (i) greatly increasing the number of electrodes with low level processing at each electrode, (ii) by optimization of electrode use after implantation using remote wireless connection, (iii) by investigating a feedback system to also monitor the reaction of the nerve during implantation, and (iv) devise microactuators to simplify the device placement and improve safety.
7. STW Valorization Grant (Phase 1) project (07880) "AIR-MARKET: Autocorrelation Impulse Radio to the Market" (2007), project leaders: dr. G. Leus and dr. W.A. Serdijn. Within this project, we investigated the development of a completely new generation of impulse-radio UWB systems based on the new design principles and (convincing) proofs-of-principle recently developed at Delft University of Technology. These principles solve the main problems associated with the current generation of impulse-radio UWB systems. The aim of the AIR-MARKET project was: (i) to consolidate all the necessary components into a coherent database of design objects, incl. architecture definition, system data, VHDL descriptions, circuit schematics, integrated circuits, implemen-tation and application notes, use cases, simulation and measurement results; and (ii) to develop a (prototype) chip set that will form the basis for the development of special applications in security, localization and telemetry systems.
6. STW project (DTC.6438) "McAT – Multi-carrier Adaptive Transceivers" (2004 – 2011), project leader: dr. W.A. Serdijn. In this project, design methodologies for the adaptive analog RF front-end of OFDM transceivers, i.e., the part of the transceiver that accommodates the varying channel, have been developed; and modulation and channel-coding techniques for OFDM transceivers, to be applied in the part of the transceiver that accommodates the varying user and application requirements, have been developed. The techniques and methodologies developed in this project have beenvalidated by both a specification and an implementation of a broadband wireless communication transceiver at 17 GHz that achieves the lowest power consumption from a system point of view for a guaranteed performance under varying application and channel conditions. The project was supported by TNO, SystematIC, Philips Research (now NXP) and National Semiconductor (now TI).
5. STW project (DTC.6418) "BioSens – Biomedical Signal Processing Platform for Low-Power Real Time Sensing of Cardiac Signals" (2004 – 2009), projectleader: dr. W.A. Serdijn. This project, by means of i) the mathematical modeling of cardiac signals and pathologies, ii) the design of WT-based algorithms for intelligent sensing and feature extraction, and iii) the development of low-power analog integrated circuits that implement the required wavelet transform and artifact detection, taking into account the limitations imposed by an implantable device, produced, apart from scientific publications, the materialization of the scientific research efforts into validated prototypes of pacemaker and implantable cardio defibrillator front-ends. The project’s primary user was Medtronic. Other users of the project were: Vitatron, Maastricht Instruments, SystematIC Design, Weijand R&D Consultancy and Twente Medical Systems International.
4. Freeband Impulse project (DTC.5961) "AIR-LINK" (2002 – 2007). Dr. Serdijn has been workpackage leader in the Freeband Impulse project "AIR-LINK" (Ad-hoc Impulse Radio -- Local Instantaneous NetworK), aiming at high-quality, wireless short-distance communication, employing Ultra-Wide Band radio. In the AIR-LINK project unique, groundbreaking scientific research has been done on the performance analysis and design of UWB transceivers and networks employing autocorrelation. Users of the project were: ASTRON, National Semiconductor, Intersil, Agere Systems, WMC, Philips, Vodafone and the Ministry of Defense. The results of the project are being valorized by 3UB B.V.
3. STW project (DEL.3943) "Design and Realisation of Electronic Systems and Circuits for subminiature hearing aids with strongly directional microphone arrays" (1998 – 2003), project leaders: dr. A.C. van der Woerd and dr. W.A. Serdijn. In this project, a first step towards the development of a pair of hearing spectacles was made. The project enjoyed an active utilization committee, comprising representatives from Amsterdam Medical Center, Amsterdam / Duran Audio BV, Zaltbommel / SonionMicrotronic Nederland BV, Amsterdam / Nederlandse Vereniging voor Slechthorenden, Houten / Beltone Netherlands BV, Eindhoven. Results of the project were described in a patent application (EP 0 924 958 A1) describing the inventions that form the basis of the "Varibel".
2. UBICOM project (1997-2002): Dr. Serdijn has been project leader in the Ubiquitous Communications (UbiCom) project of Delft University of Technology. The UbiCom project has laid to a solid foundation for multidisciplinary research in personal mobile computing and communications. The participating research groups were active in UbiCom in the following discipline fields: (i) micro-electronics for low-power wireless communications transceivers, (ii) signal processing for high bandwidth high frequency wireless communications, (iii) multimedia (video and graphics) processing, (iv) sensor data (video and location signals, GIS databases) analysis and fusion for context awareness, (v) augmented reality display technology and usability, (vi) quality of service architectures, (vii) quality of service protocols and programming.
1. STW project (DEL33.3251) “Ultra Low-Power Electronics” (1994 – 1998), project leader: dr. W.A. Serdijn. Within this project design methodologies and proof-of-concepts have been developed for low-power low-voltage circuits for biomedical systems, such as wearable, implantable and injectable devices, among them being hearing instruments and pacemakers. Major design constraints that were taken into account are reliability, low-voltage (1 – 3 volt) and ultra low-power (<< 1mW) operation. The project enjoyed an active utilization committee, comprising representatives from Amsterdam Medical Center, Twente University, Ericsson, Vitatron Medical, Philips Semiconductors and Philips Hearing Instruments (now Beltone).